https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30472 Wed 11 Apr 2018 12:58:04 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41409 Wed 03 Aug 2022 11:24:21 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45541 2) to investigate effects of fish oil (2000 mg docosahexaenoic acid + 400 mg eicosapentaenoic acid/day), curcumin (160 mg/day) or a combination of both on cerebrovascular function (measured by Transcranial Doppler ultrasound), systemic vascular function (blood pressure, heart rate and arterial compliance) and cardiometabolic (fasting glucose and blood lipids) and inflammatory (C-reactive protein) biomarkers. The primary outcome, cerebrovascular responsiveness to hypercapnia, was not affected by the interventions. However, cerebral artery stiffness was significantly reduced in males following fish oil supplementation (P = 0.007). Furthermore, fish oil reduced heart rate (P = 0.038) and serum triglycerides (P = 0.006) and increased HDL cholesterol (P = 0.002). Curcumin did not significantly affect these outcomes either alone or in combination with fish oil. Conclusion: Regular supplementation with fish oil but not curcumin improved biomarkers of cardiovascular and cerebrovascular function. The combined supplementation did not result in additional benefits. Further studies are warranted to identify an efficacious curcumin dose and to characterize (in terms of sex, BMI, cardiovascular and metabolic risk factors) populations whose cerebrovascular and cognitive functions might benefit from either intervention. Clinical trial registration: ACTRN12616000732482p.]]> Tue 14 Nov 2023 14:41:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33423 Tue 03 Sep 2019 18:01:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41204 Thu 28 Jul 2022 11:26:39 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38520 Mon 09 May 2022 16:19:34 AEST ]]>